ALS Related Publications

We are employing a combination of human induced pluripotent stem cells, stem-cell derived neurons, and mouse models to study the disease mechanisms underlying ALS and to identify novel therapeutic pathways.


Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging.

Tian F, Yang W, Mordes DA, Wang JY, Salameh JS, Mok J, Chew J, Sharma A, Leno-Duran E, Suzuki-Uematsu S, Suzuki N, Han SS, Lu FK, Ji M, Zhang R, Liu Y, Strominger J, Shneider NA, Petrucelli L, Xie XS, Eggan K.

NatCommun. 2016 Oct 31;7:13283. doi: 10.1038/ncomms13283. PubMed PMID: 27796305.


Loss-of-function mutations in the C9ORF72 mouse orthologcause fatal autoimmune disease.

Burberry A, Suzuki N, Wang JY, Moccia R, Mordes DA, Stewart MH, Suzuki-Uematsu S, Ghosh S, Singh A, Merkle FT, Koszka K, Li QZ, Zon L, Rossi DJ, Trowbridge JJ, Notarangelo LD, Eggan K.

Sci Transl Med. 2016 Jul 13;8(347):347ra93. doi: 10.1126/scitranslmed.aaf6038. PubMed PMID: 27412785; PubMed Central PMCID: PMC5024536.


Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons.

Toma JS, Shettar BC, Chipman PH, Pinto DM, Borowska JP, Ichida JK, Fawcett JP, Zhang Y, Eggan K, Rafuse VF.

J Neurosci. 2015 Jan 21;35(3):1291-306. doi: 10.1523/JNEUROSCI.2126-14.2015. PubMed PMID: 25609642; PubMed Central PMCID: PMC4402330.

A perspective on stem cell modeling of amyotrophic lateral sclerosis.

de Boer AS, Eggan K.

Cell Cycle. 2015;14(23):3679-88. doi: 10.1080/15384101.2015.1093712. Review. PubMed PMID: 26505672; PubMed Central PMCID: PMC4825790.

FUS is sequestered in nuclear aggregates in ALS patient fibroblasts.

Schwartz JC, Podell ER, Han SS, Berry JD, Eggan KC, Cech TR.

Mol Biol Cell. 2014 Sep 1;25(17):2571-8. doi: 10.1091/mbc.E14-05-1007. PubMed PMID: 25009283; PubMed Central PMCID: PMC4148247.