Neurodevelopmental and Psychiatric Disease Related Publications

Based on our initial successes in contributing to the understanding of motor neuron disease, we have now begun to expand our interests, using human induced pluripotent stem cells, stem-cell derived neurons, and mouse models to study neurodevelopmental and psychiatric conditions in collaboration with The Stanley Center at The Broad Institute.


Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection.

Wells MF, Salick MR, Wiskow O, Ho DJ, Worringer KA, Ihry RJ, Kommineni S, Bilican B, Klim JR, Hill EJ, Kane LT, Ye C, Kaykas A, Eggan K.

Cell Stem Cell. 2016 Dec 1;19(6):703-708. doi:
10.1016/j.stem.2016.11.011. PubMed PMID: 27912091.



SLC52A3, A Brown-Vialetto-van Laere syndrome candidate gene is essential for mouse development, but dispensable for motor neuron differentiation.

Intoh A, Suzuki N, Koszka K, Eggan K.

Hum Mol Genet. 2016 May 1;25(9):1814-23. doi:

10.1093/hmg/ddw053. PubMed PMID: 26976849; PubMed Central PMCID: PMC4986335.

Generation Merkle.jpg

Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells.

Merkle FT, Maroof A, Wataya T, Sasai Y, Studer L, Eggan K, Schier AF.

Development. 2015 Feb 15;142(4):633-43. doi: 10.1242/dev.117978. PubMedPMID: 25670790; PubMed Central PMCID: PMC4325380.


From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial.

McNeish J, Gardner JP, Wainger BJ, Woolf CJ, Eggan K.

Cell Stem Cell. 2015 Jul 2;17(1):8-10. doi:10.1016/j.stem.2015.06.013. PubMed PMID: 26140603.


Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.

Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ.

Nat Neurosci. 2015 Jan;18(1):17-24. doi: 10.1038/nn.3886. PubMed PMID: 25420066; PubMed Central PMCID: PMC4429606.